Characteristics of Pediatric Stroke and Association of Delayed Diagnosis with Mortality in a Mexican Tertiary Care Hospital.

BACKGROUND AND OBJECTIVES: Pediatric cerebrovascular disease carries significant morbidity and mortality. Early recognition of a pediatric stroke as well and its most common risk factors are important, but that diagnosis is often delayed. It is believed that the incidence in our center is higher than it appears. This study aims to assess the incidence and characteristics of the pediatric stroke in our university hospital. Likewise, this study seeks to evaluate if a longer symptoms-to-diagnosis time is associated with mortality in patients with ischemic stroke. METHODS: A retrospective study including children with stroke admitted to the UANL University Hospital from January 2013 to December 2016. RESULTS: A total of 41 patients and 46 stroke episodes were admitted. About 45.7% had an ischemic stroke and 54.3% had a hemorrhagic stroke. A mortality of 24.4% and a morbidity of 60.9% were recorded. Regarding ischemic and hemorrhagic stroke, an increased symptoms-to-diagnosis time and a higher mortality were obtained with a relative risk of 2.667 (95% confidence interval [CI]: 1.09-6.524, p = 0.013) and 8.0 (95% CI: 2.18-29.24, p = < 0.0001), respectively. A continuous increase in the incidence rate, ranging from 4.57 to 13.21 per 1,000 admissions comparing the first period (2013) versus the last period (2016), p = 0.02, was found in our center. CONCLUSIONS: Pediatric stroke is a rare disease; however, its incidence shows a continuous increase. More awareness toward pediatric stroke is needed.

Características del embarazo y nacimiento en el Noreste de México y correlación con la evaluación neurológica del recién nacido / Pregnancy and delivery characteristics in northeastern Mexico and their correlation with neonatal neurological evaluation

Resumen OBJETIVO: Determinar las características del embarazo y nacimiento en hospitales públicos del estado de Nuevo León y analizar los resultados de la valoración neurológica de los recién nacidos. MATERIALES Y MÉTODOS: Estudio de serie de casos, ambispectivo, multicéntrico, aleatorizado y transversal efectuado del 2017 al 2020 en tres hospitales públicos de Nuevo León, México. La muestra se reclutó de madres en puerperio seleccionadas en forma aleatoria y recién nacidos con la valoración Neo Neuro and Up de Sheridan Perreira. RESULTADOS: De 75,951 madres en puerperio inmediato, asignadas al azar, se estudiaron 4241. El 87.2% eran residentes de Nuevo León y 12.7% de otros estados del Noreste de México. El 39.9% tuvieron control prenatal en los hospitales de nacimiento de sus hijos. El 51.0% nacieron por parto eutócico y 27.4% por cesárea programada. El 9.6% de los recién nacidos fueron pretérmino. Las características pre y perinatales más frecuentes fueron: infección urinaria y prematurez. El 12.02% de los recién nacidos tuvieron evaluación neurológica neonatal anormal. Los factores de riesgo para evaluación neurológica anormal al nacimiento fueron: peso al nacer menor de 2500 g, bajo peso para la edad gestacional, cesárea urgente y perímetro cefálico menor de 30 cm. CONCLUSIONES: Las características de las embarazadas del Noreste de México han sido poco estudiadas, casi la tercera parte ellas son adolescentes con un nivel importante de pobreza. Existe una relación significativa entre algunas características del parto relacionadas con una evaluación neurológica anormal del recién nacido.

Abstract OBJECTIVE: To determine the characteristics of pregnancy and birth in public hospitals in northeastern Mexico. Analyze the results of the neurological evaluation of newborns MATERIALS AND METHODS: Case series, ambispective, multicenter, randomized, cross-sectional study conducted from 2017 to 2020 in three public hospitals in Nuevo León, Mexico. The sample was recruited from randomly selected puerperium mothers and newborns with Sheridan Perreira's Neo Neuro and Up assessment. RESULTS: Of 75,951 mothers in immediate puerperium, randomly assigned, 4,241 were studied. Eighty-seven percent were residents of Nuevo León and 12.7% were from other states in northeastern Mexico. Thirty-nine.9% had prenatal care in the hospitals where their children were born. Fifty-one percent were born by euthyroid delivery and 27.4% by programmed cesarean section. Of the newborns, 9.6% were preterm. The most frequent pre and perinatal characteristics were urinary tract infection and prematurity. Abnormal neonatal neurological evaluation was observed in 12.02% of the newborns. The risk factors for abnormal neurological evaluation at birth were birth weight less than 2500 g, low weight for gestational age, emergency cesarean section and head circumference less than 30 cm. CONCLUSSIONS: The characteristics of pregnant mothers in northeastern Mexico have been little studied, almost a third of these mothers are adolescents with a significant level of poverty. There is a significant relationship between some characteristics of delivery related to an abnormal neurological evaluation of the newborn.